THORNE Methyl-Guard Plus Active Folate B-Vitamin Complex — 90 Capsules, Methylcobalamin & 5-MTHF for Methylation Support

THORNE Methyl-Guard Plus is a concentrated B-vitamin complex delivering active folate (5-MTHF), methylcobalamin B12, and supporting methyl donors to support healthy methylation pathways.

Designed for people who want bioavailable forms of folate and B vitamins, Methyl-Guard Plus supplies methyl donors and cofactors in forms the body can readily use. The formula emphasizes active folate (5-MTHF), methylcobalamin, and complementary nutrients like riboflavin (B2), pyridoxal-5-phosphate (B6), and betaine to support cellular methylation processes and maintain balanced homocysteine levels in the bloodstream.* Thorne applies rigorous testing protocols across raw materials and finished goods to ensure quality and consistency.

How does Methyl-Guard Plus support daily methylation?

This product provides nutrients that participate in methyl transfer cycles, supporting biochemical reactions involved in methylation. Using active vitamin forms reduces the metabolic steps required for conversion, which can be helpful for individuals with genetic variations that affect folate metabolism.

• Contains 5-MTHF (active folate) for direct use by cells
• Includes methylcobalamin, the methyl form of vitamin B12
• Supplies riboflavin (B2) and pyridoxal-5-phosphate (B6) as cofactors
• Provides betaine as an additional methyl donor

Who should consider taking an active folate formula?

People seeking an easily utilized folate source, those with known MTHFR or related genetic variants, and individuals aiming to support metabolic pathways involving homocysteine may consider active folate formulas. Consultation with a healthcare professional is recommended to determine personal suitability and dosing.

• Individuals with impaired folate conversion
• Adults wanting targeted B-vitamin support
• Those monitoring homocysteine as part of cardiovascular or metabolic care
• Practitioners preferring methylated nutrient forms

What are the practical benefits of the capsule format and testing standards?

Each capsule provides a measured dose of active nutrients for convenient daily use. Thorne performs multiple rounds of testing—from raw material validation to finished product stability—so each bottle meets consistent potency and purity expectations.

• 90 easy-to-swallow capsules per bottle
• Four rounds of laboratory testing confirm quality
• Capsules allow precise dosing and simple integration into routines
• Trusted by practitioners and professional organizations

How should this supplement be incorporated into a routine?

Follow the label directions or your clinician’s advice for dosing and timing. Taking the capsule with food can aid absorption of cofactor nutrients, and pairing with a comprehensive diet supports broader nutrient status.

• Take as directed on the product label or by a practitioner
• Consider with a meal to support absorption
• Combine with a balanced diet for best overall nutrient support
• Discuss use with healthcare providers if pregnant, nursing, or medicated

Who is this for? THORNE Methyl-Guard Plus is aimed at adults seeking targeted methylation support through bioactive folate and B-vitamins—especially those who prefer methylated nutrient forms or who have metabolic reasons to choose active cofactors. It is suitable for people working with healthcare practitioners to optimize nutritional support; it is not a substitute for medical advice or treatment.*

Ingredients

Three Capsules Contain: Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg, Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg, Folate (3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE, Vitamin B12 (as Methylcobalamin) 3 mg, Betaine Anhydrous (Trimethylglycine) 1.8 g
Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.